Comparative study on acute gastric mucosal lesion in experimental obstructive jaundice and biliary drainage models.

The authors prepared obstructive jaundice models by cannulation into the common bile duct, using Wistar-strain rats, and examined active amines in the gastric wall and the incidence of AGML before and after biliary drainage. 1) The incidence of AGML was comparatively high in the group of 1-3 weeks' obstruction, while the incidence was greatly reduced after biliary drainage in the groups of 1-2 weeks' obstruction. 2) HA and 5-HT contents in the gastric walls were significantly high in the group of 1-3 weeks' obstruction, while biliary drainage succeeded in gradually reducing the levels down to the control values in the group of 1-2 weeks' obstruction. 3) In 3 weeks' obstruction, the increase in HA was not improved after biliary drainage and the incidence of AGML was similar to 1 week's obstruction on the 5th day after biliary drainage. It was suggested therefore that there was an intimate relationship between the changes in the active amines contents in gastric walls and the incidence of AGML, and the obstructive jaundice was a pathological state where active amines in the gastric walls were markedly increased, and that such a state was associated with the mechanism of onset of AGML in obstructive jaundice. 479